Christian Zierhut, PhD
Head of Laboratory
Christian then did postdoctoral work with Hironori Funabiki at Rockefeller University. Here, he showed that chromatin is essential for the assembly of the nuclear envelope and the mitotic spindle. Subsequently, he showed that chromatin acts as a mark of self-DNA, preventing activation of self-sensing by cGAS.
Christian joined the Cancer Biology Division of the ICR as a Team Leader in 2020.
Negar Afshar, PhD
Higher Scientific Officer
For her PhD, she joined Professor Hiroshi Iwasaki’s lab at the Tokyo Institute of Technology, studying the molecular mechanism of mitotic homologous recombination (HR). More specifically analysing the relationship between Rad51 and HR auxiliary factors and identifying a novel motif of Rad51 that is responsible for interaction with multiple auxiliary factors.
Negar joined the lab as a Higher Scientific Officer in 2021.
Robert Pickering, PhD
Robert graduated with a BSc in Biological Sciences from the University of Leeds. Following this, he obtained his MRes from Cardiff University working with Professor Helen White-Cooper on the transcriptional regulation of spermatogenesis.
Following his PhD, he worked as a postdoctoral research associate with Professor Clare Bryant in her labs at the University of Cambridge and GlaxoSmithKline working on inflammasomes. Robert joined the lab as a RadNet Postdoctoral Fellow for a joint project with Pascal Meier, Jyoti Choudhary and Jon Pines in 2021.
Laboratory of Genome Stability and Innate Immunity