Head of Laboratory
Christian then did postdoctoral work with Hironori Funabiki at Rockefeller University. Here, he showed that chromatin is essential for the assembly of the nuclear envelope and the mitotic spindle. Subsequently, he showed that chromatin acts as a mark of self-DNA, preventing activation of self-sensing by cGAS.
Christian joined the Cancer Biology Division of the ICR as a Team Leader in 2020.
Higher Scientific Officer
For her PhD, she joined Professor Hiroshi Iwasaki’s lab at the Tokyo Institute of Technology, studying the molecular mechanism of mitotic homologous recombination (HR). More specifically analysing the relationship between Rad51 and HR auxiliary factors and identifying a novel motif of Rad51 that is responsible for interaction with multiple auxiliary factors.
Negar joined the lab as a Higher Scientific Officer in 2021.
Vicente obtained his undergraduate degree from the Pierre and Marie Curie University in Paris, where he studied meiosis in the lab of Catherine Jessus.
For his PhD, he joined Olivier Gavet’s group at the Gustave Roussy institute, where he studied the DNA damage response to replication stress. More specifically, he developed fluorescent reporters to monitor activation of the Chk1 pathway in live single cells and uncovered unexpected heterogeneity of Chk1 activity kinetics in cell populations exposed to replication stress.
Vicente joined the lab as a Postdoctoral Fellow in 2021.
Robert graduated with a BSc in Biological Sciences from the University of Leeds. Following this, he obtained his MRes from Cardiff University working with Professor Helen White-Cooper on the transcriptional regulation of spermatogenesis.
Following his PhD, he worked as a postdoctoral research associate with Professor Clare Bryant in her labs at the University of Cambridge and GlaxoSmithKline working on inflammasomes. Robert joined the lab as a RadNet Postdoctoral Fellow for a joint project with Pascal Meier, Jyoti Choudhary and Jon Pines in 2021.
Federico obtained a BSc in Biotechnology and a MSc in Industrial Biotechnology from the University of Rome Tor Vergata.
For his PhD, he joined Jan Fric’s lab at the International Clinical Research Center (ICRC) in Brno, where he investigated innate immune signalling in mesenchymal stromal cells, with a focus on the role of Calcineurin-NFAT signaling during fungal infection.
Federico joined the lab as a postdoctoral fellow in 2021
Laboratory of Genome Stability and Innate Immunity